Poly(ADP-ribose) Polymerase 1 Interacts with Nuclear Respiratory Factor 1 (NRF-1) and Plays a Role in NRF-1 Transcriptional Regulation

Poly(ADP-ribose) Polymerase 1 Interacts with Nuclear Respiratory Factor 1 (NRF-1) and Plays a Role in NRF-1 Transcriptional Regulation.

Nuclear respiratory factor 1 (NRF-1) is one of the key transcriptional activators for nuclear-coded genes involved in mitochondrial biogenesis and function as well as for many housekeeping genes. A transcriptional co-activator PGC-1 and its related family member PRC have previously been shown to interact with NRF-1 and co-activate NRF-1. We show here that NRF-1 can also directly interact with p...

SKN-1/Nrf, A New Unfolded Protein Response Factor?

Cell function requires simultaneous regulation of numerous processes, often under variable conditions. Several inducible pathways have been defined as being responsible for maintaining homeostasis under the threat of a particular stress such as heat, oxidizing conditions, exposure to pathogens, or loss of proteostasis. The challenge now is to understand how and why these pathways interact in ba...

Inhibition of microRNA-182 reduces hypoxia/re-oxygenation-induced HL-1 cardiomyocyte apoptosis by targeting the nuclear respiratory factor-1/mitochondrial transcription factor A (NRF-1/mtTFA) pathway

Apoptosis is a component of cardiac remodeling following myocardial ischemia and infarction. MicroRNAs (miRNAs) are involved in regulating a range of cellular biological processes, including apoptosis, by regulating gene expression at the post-transcriptional level. Nuclear respiratory factor-1 (NRF-1) is a transcriptional activator of nuclear genes that encode a range of mitochondrial proteins...

NRF-1: a trans-activator of nuclear-encoded respiratory genes in animal cells.

The assembly of the respiratory apparatus requires the coordinate expression of a large number of genes from both nuclear and mitochondrial genetic systems. In vertebrate organisms, the molecular mechanisms integrating the activities of these distinct genomic compartments in response to tissue demands for respiratory energy remain unknown. A potential inroad to this problem came with the discov...

Clinicopathological significance of nuclear factor 1 ( erythroid - 2 ) - related factor 2 ( Nrf 2 ) expression in gastric